Actual Scientific Program

of

FEBSSysBio2005

Edition 4/18/2005 12:33 PM

Saturday March 12

Course Registration & Hotel Check-In 11:00 am - 6:00 pm

Welcome Reception 6:00 pm - 6:45 pm

Official Course Opening 6:45 pm - 6:55 pm

Hans Westerhoff and Karl Kuchler

FEBS Opening Lecture

(M-L2) Boris Kholodenko 7:00 pm – 8:00 pm

Systems biology of receptor tyrosine kinase signaling

Welcome Dinner & Musical performance 8:30 pm - open end

Subhendu Ghosh Patterns of Passion

AstraZeneca Opening Lecture

(M-L2) Douglas Kell 10:30 pm – 11:30 pm

Metabolomics, machine learning and modelling in systems biology: towards an understanding of the language of cells

Sunday March 13

Breakfast 7:00 - 8:30 am

rinciples of Systems Biology Lectures 8:30 am - 12:30 pm

Chair: Hans Westerhoff

Co-chair: Lilia Alberghina

P-L1 Reinhart Heinrich 8:30 - 9:15

Dynamics and design of cellular reaction networks

P-L2 John Doyle 9:15 - 10:00

Organizational complexity

Coffee & Refreshment Break 10:00 - 10:20

P-L3 Albert Goldbeter 10:20 -11:05

Computational approaches to cellular rhythms

P-L4 Stefan Schuster 11:05 - 11:50

Fundamentals and applications of metabolic pathway analysis

Break 11:50 – 12:00

Guided General Discussion: Identifying issues; SB Principles 12:00 - 12:30 pm

Lunch & Afternoon Break 12:30 - 4:30 pm

Coffee and Tea Break 4:00 – 4:30 pm

Chalk/Blackboard teaching 4 in parallel 4:30 – 5:10 pm

PT-B1 Uri Alon Motifs and networks

PT-B2 Reinhart Heinrich/Stefan Schuster Stability and flux mode analysis

PT-B3 Jacky Snoep/Hans Westerhoff Control analysis and Silicon cells

PT-B4 Jörg Stelling/Frank Bruggeman Robustness, network identification and engineering

rinciples of Systems Biology Workshop & Short Talks 5:15 – 7:00 pm

Chair: Lilia Alberghina

Co-chair: Hans Westerhoff

P-W1 Dennis Vitkup 5:15 - 5:35

Expression dynamics of a cellular metabolic network

P-S1 Frank Bruggeman 5:35 - 5:50

Smart regulation of ammonium assimilation by Escherichia coli: modularity, robustness, and flux regulation

Coffee & Refreshment Break 5:50 - 6:10

P-W2 Sinisa Zampera 6:10 -6:30

An adaptive system approach for the modelling of genetic regulatory networks

Glucose metabolism study in the yeast

P-S2 Markus Kollmann 6:30 - 6:45

Design principles of signal transduction pathways to attenuate noise

P-S3 Esa Pitkänen 6:45- 7:00

On pathways and distances in metabolic networks

Resumed General Discussion: Addressing the issues; SB principles 7:00 - 7:30

Dinner 7:30 - 9:00 pm

Poster Session 1 9:00 - 11:00 pm

Viewing posters 9:00 - 9:45

Free poster wandering 9:45 – 10:30

Round table poster discussion (presenters and teachers only) 10:30 – 11:00

Monday March 14

Breakfast 7:00 - 8:30 am

ools and methods (part 1) Lectures 8:30 am - 12:30 pm

Chair: Karl Kuchler

Co-chair: Igor Goryanin

T-L1 Rudi Aebersold 8:30 - 9:15

Quantitative Proteomics: An essential component of systems biology

T-L2 Roland Eils 9:15 - 10:00

Modelling and simulation of large-scale signal transduction networks

Coffee & Refreshment Break 10:00 - 10:20

U-L5* Uri Alon 10:20 - 11:05

Simplicity in Biology

T-L4 Charlie Boone 11:05 - 11:50

Global mapping of synthetic genetic interactions in yeast

Break 11:50 – 12:00

Guided General Discussion: Identifying issues; Tools, Methods 12:00 - 12:30

Lunch & Afternoon Break 12:30 - 4:30 pm

Coffee and Tea Break 4:00 – 4:30 pm

Chalk/Blackboard teaching 4 in parallel (repeat) 4:30 – 5:10 pm

PT-B1 Uri Alon Motifs and networks

PT-B2 Reinhart Heinrich/Stefan Schuster Stability and flux mode analysis

PT-B3 Jacky Snoep/Hans Westerhoff Control analysis and Silicon cells

PT-B4 Jörg Stelling/Frank Bruggeman Robustness, network identification and engineering

Coffee & Refreshment Break 5:10 - 5:35

ools and methods Workshop & Short talks 5:35 - 7:00 pm

Chair: Igor Goryanin

Co-chair: Karl Kuchler

T-W1 An-Ping Zeng 5:35 - 5:55

An integrated interaction network of Escherichia coli for studying genotype-phenotype relationship

T-S1 Sune Danø 5:55 - 6:10

Oscillatory mechanisms derived from phase and amplitude information

Coffee & Refreshment Break 5:50 - 6:10

T-S2 Adrienne James 6:10 - 6:30

Application of modelling and simulation to drug discovery: The ErbB system

T-S3 Konstantin Kozlov 6:30 - 6:45

Combined optimization technique for biological data fitting

T-S4 Balázs Papp 6:45- 7:00

Systematic identification and characterisation of synthetic lethal interactions in the metabolic network of yeast

Resumed General Discussion: Addressing the issues Tools & Methods 7:00 - 7:30

Dinner 7:30 - 9:00 pm

Poster Session 2 9:00 - 11:00 pm

Viewing posters 9:00 - 9:45

Free poster wandering 9:45 – 10:30

Round table poster discussion (presenters and teachers only) 10:30 – 11:00

Tuesday March 15

Breakfast 7:00 - 8:30 am

ools & Methods (part 2) Lectures 8:30 am - 10:00 pm

Chair: Karl Kuchler

T-L5 Jacky Snoep 8:30 - 9:15

The Silicon Cell approach to building detailed kinetic models of biological systems

T-L6 Ursula Kummer 9:15 - 10:00

Mathematical modelling: Choosing the right simulation method

Coffee & Refreshment Break 10:10 - 10:20

nicellular Organisms (part 1) Lectures 10:20 am - 12:35 pm

Chair: Stefan Hohmann

U-L7* Masaru Tomita 10:20 - 11:05

Metabolome analysis and systems biology

U-L2 Matthias Reuss 11:05 - 11:50

Hiding behind the population average - cell cycle dynamics of energy metabolism during the lifelines of individual yeast cells

U-L3 Jörg Stelling 11:50 - 12:35

Knowledge and data requirements for systems analysis of cellular networks

Lunch & Afternoon Break 12:35 – 13:15

VISIT to SALZBURG 13:30 – 23:00 pm

Buses will leave Hotel at 13:30 pm

Dinner in Salzburg

Return from Salzburg to the venue 22:00 pm

Wednesday March 16

Breakfast 7:00 - 8:30 am

nicellular Organisms (part 2) Lectures 8:30 am - 12:30 pm

Chair: Stefan Hohmann

Co-chair:Matthias Reuss

U-L4 Uwe Sauer 8:30 - 9:15

In vivo operation of metabolic pathways

U-L7¹ Igor Goryanin 9:15 - 10:00

Computational Systems Biology: Applications for the Pharmaceutical Industry

Coffee & Refreshment Break 10:00 - 10:20

U-L6 Barry Wanner 10:20 - 11:05

Stochastic activation of the response regulator PhoB by noncognate histidine kinases

U-L1¹ Edda Klipp 11:05 - 11:50

Mathematical modeling of stress response in yeast

Break 11:50 – 12:00

Guided General Discussion: Identifying issues; unicellular organisms 12:00 - 12:30

Lunch & Afternoon Break 12:30 - 4:30 pm

Coffee and Tea Break 4:00 – 4:30 pm

nicellular Organisms Workshop & Short Talks 4:30 - 6:50 pm

Chair: Matthias Reuss

Co-chair: Stefan Hohmann

U-W1 Guillaume Beslon 4:30 - 4:50

Modelling evolution of prokaryotic genomes: an integrative approach

U-W2 Victor Sourjik 4:50 - 5:10

Signal processing in bacterial chemotaxis

U-W3 Bas Teusink 5:10 - 5:30

Combining experimental data and in silico analysis to model the metabolic and regulatory network of Lactobacillus plantarum

Coffee & Refreshment Break 5:30 - 5:50

U-S1 Attila Csikasz-Nagy 5:50 - 6:05

Modelling fission yeast morphogenesis

U-S2 Silvia De Monte 6:05 - 6:20

Metabolic quorum sensing: onset of density-dependent oscillations

U-S3 Ana Sofia Figueiredo 6:20- 6:35

Integration of software tools for the in silico design of metabolic pathways using flux balance analysis

U-S4 Douglas Murray 6:35- 6:50

Uncovering the control of the respiratory clock in yeast

Resumed General Discussion: Addressing the issues; unicellular organisms 6:50- 7:30

Dinner 7:30 - 9:00 pm

Poster Session 3 9:00 - 11:00 pm

Viewing posters 9:00 - 9:45

Free poster wandering 9:45 – 10:30

Round table poster discussion (presenters and teachers only) 10:30 – 11:00

Thursday March 17

Breakfast 7:00 - 8:30 am

ulticellular Organisms Lectures 8:30 am - 12:30 pm

Chair: Hiraoki Kitano

Co-chair: Mattias Reuss

M-L1 Michel Eichelbaum 8:30 - 9:15

Pharmacogenomics: a holistic approach to drug organism interaction

T-L3* Shoshana Wodak 9:15 - 10:00

Analysing networks of biochemical processes: Bioinformatics meets systems biology

9:15 - 10:00

Coffee & Refreshment Break 10:00 - 10:20

M-L3 Nicolas Le Novere 10:20 - 11:05

Computational systems biology of neuronal signalling

M-L4 Ursula Klingmüller 11:05 - 11:50

Signal transduction and cancer – generation of high quality quantitative data

Break 11:50 – 12:00

Guided General Discussion: Identifying issues; multicellular organisms 12:00 - 12:30

Lunch & Afternoon Break 12:30 - 4:30 pm

Coffee and Tea Break 4:00 – 4:30 pm

ulticellular Organisms Workshop & Short Talks 4:30 -5:55 pm

Chair: Mattias Reuss

Co-chair: Hiraoki Kitano

M-W1 Mariko Hatakeyama 4:30 - 4:50

Computer simulation analysis of ErbB signaling for understanding of cellular transformation mechanism

M-W2 Thomas Höfer 4:50 - 5:10

Integration of signal transduction and cytokine expression in T lymphocytes

M-S1 Nils Bluethgen 5:10 - 5:25

Inferring feedback mechanisms in cellular transformation due to oncogenic RAS

M-S2 Silvia Santos 5:25 - 5:40

Regulation of MAPK signalling determining cell fate in PC-12 cells - a step beyond biochemistry

M-S3 Thomas Sauter 5:40- 5:55

Mathematical modeling of neuronal response to neuropeptides: Angiotensin II signaling via G-protein coupled receptor

Coffee & Refreshment Break 5:55 - 6:15

Resumed General Discussion:Addressing the issues; multicellular organisms 6:15 - 6:45

NovoNordisk Closing Lecture

Denis Noble 7:00 pm – 8:00 pm

Highlights of SysBio2005: From genes to whole organs

Vertical integration using mathematical simulation

Presentation of “Gosau YOUNG SysBio INVESTIGATOR AWARDS” 8:00 - 8:15

Marta Cascante, Lilia Alberghina, Roel van Driel, Stefan Hohmann

Banquet (Restaurant) 8:15 pm – 9:45

Official Course Closure 9:45 - 10:00

Hans Westerhoff and Karl Kuchler

Farewell Party (Lecture Hall) 10:00 pm - open end