| 
    Chapter  | 
  
   Authors  | 
  
   Title  | 
 
| 
      | 
  
   INTRODUCTION  | 
  
      | 
 
| 
   1  | 
  
   Lilia Alberghina & Hans V.
  Westerhoff  | 
  
   Systems Biology; did we know it all
  along?  | 
 
| 
      | 
  
   TOOLS  | 
  
      | 
 
| 
   2  | 
  
   Jacky L. Snoep & Hans V. Westerhoff  | 
  
   From isolation to integration; a systems
  biology approach for building the Silicon Cell  | 
 
| 
   3  | 
  
   Oleg V. Demin, T. Yu. Plyusnina, Galina V. Lebedeva, E.A.
  Zobova, Eugeniy A. Metelkin, Alex G. Kolupaev, Frank Tobin & Igor I.
  Goryanin  | 
  
   Kinetic modelling of E. coli
  metabolism  | 
 
| 
   4  | 
  
   David A. Fell  | 
  
   Metabolic Control Analysis  | 
 
| 
      | 
  
   SYSTEMS BIOCHEMISTRY  | 
  
      | 
 
| 
   5  | 
  
   Ursula Kummer & Lars Folke Olsen  | 
  
   No music without melody:  How to understand biochemical systems by
  understanding their dynamics  | 
 
| 
   6  | 
  
   Johan Elf, Johan Paulsson, Otto Berg
  & Mĺns Ehrenberg  | 
  
   Mesoscopic kinetics and its applications
  in protein synthesis  | 
 
| 
      | 
  
   THE CELL AS A SYSTEM OF LIFE  | 
  
      | 
 
| 
   7  | 
  
   Hans V. Westerhoff & Jan-Hendrik S. Hofmeyr  | 
  
   What is Systems Biology?  From genes to function and back  | 
 
| 
   8  | 
  
   Boris N. Kholodenko, Frank J. Bruggeman & Herbert M. Sauro  | 
  
   Mechanistic and modular approaches to
  modeling and inference of celllar regulatory networks  | 
 
| 
   9  | 
  
   Michael Hucka, Andrew Finney & Barry
  L. Wanner  | 
  
   Modeling the E. coli cell:  The need for computing, cooperation, and
  consortia  | 
 
| 
      | 
  
   METABOLIC SYSTEMS BIOCHEMISTRY  | 
  
      | 
 
| 
   10  | 
  
   Uwe Sauer  | 
  
   Quantification of in vivo
  molecular fluxes:  A key methodology
  for Metabolic Systems Biology  | 
 
| 
   11  | 
  
   A. Kremling, J. Stelling, K. Bettenbrock, S. Fischer & E. D.
  Gilles  | 
  
   Metabolic networks:  Biology meets Engineering Sciences  | 
 
| 
   12  | 
  
   Dirk Müller, Luciano Aguilera-Vázquez, Matthias Reuss &
  Klaus Mauch  | 
  
   Integration of metabolic and signaling
  networks  | 
 
| 
      | 
  
   SIGNAL TRANSDUCTION  | 
  
      | 
 
| 
   13  | 
  
   Reinhart Heinrich  | 
  
   Mathematical modelling of the
  Wnt-pathway  | 
 
| 
   14  | 
  
   Bodil Nordlander, Edda Klipp, Bente Kofahl & Stefan Hohmann  | 
  
   Modelling signallng pathways – A yeast
  approach  | 
 
| 
      | 
  
   LIFE AND DEATH  | 
  
      | 
 
| 
   15  | 
  
   Béla Novák, Katherine C. Chen and John
  J. Tyson  | 
  
   Systems Biology of the yeast cell cycle
  engine  | 
 
| 
   16  | 
  
   M. Bentele & Roland Eils  | 
  
   Systems Biology of Apoptosis  | 
 
| 
   17  | 
  
   Hiroaki Kitano  | 
  
   Scientific and technical challenges for
  Systems Biology  | 
 
| 
      | 
  
   EPILOGUE  | 
  
      | 
 
| 
   18  | 
  
   Lilia Alberghina, Stefan Hohmann and
  Hans V. Westerhoff  | 
  
   Systems Biology: recent developments and
  new trends  | 
 
| 
      | 
  
      | 
  
      |