Chapter

Authors

Title

 

INTRODUCTION

 

1

Lilia Alberghina & Hans V. Westerhoff

Systems Biology; did we know it all along?

 

TOOLS

 

2

Jacky L. Snoep & Hans V. Westerhoff

From isolation to integration; a systems biology approach for building the Silicon Cell

3

Oleg V. Demin, T. Yu. Plyusnina, Galina V. Lebedeva, E.A. Zobova, Eugeniy A. Metelkin, Alex G. Kolupaev, Frank Tobin & Igor I. Goryanin

Kinetic modelling of E. coli metabolism

4

David A. Fell

Metabolic Control Analysis

 

SYSTEMS BIOCHEMISTRY

 

5

Ursula Kummer & Lars Folke Olsen

No music without melody:  How to understand biochemical systems by understanding their dynamics

6

Johan Elf, Johan Paulsson, Otto Berg & Mĺns Ehrenberg

Mesoscopic kinetics and its applications in protein synthesis

 

THE CELL AS A SYSTEM OF LIFE

 

7

Hans V. Westerhoff & Jan-Hendrik S. Hofmeyr

What is Systems Biology?  From genes to function and back

8

Boris N. Kholodenko, Frank J. Bruggeman & Herbert M. Sauro

Mechanistic and modular approaches to modeling and inference of celllar regulatory networks

9

Michael Hucka, Andrew Finney & Barry L. Wanner

Modeling the E. coli cell:  The need for computing, cooperation, and consortia

 

METABOLIC SYSTEMS BIOCHEMISTRY

 

10

Uwe Sauer

Quantification of in vivo molecular fluxes:  A key methodology for Metabolic Systems Biology

11

A. Kremling, J. Stelling, K. Bettenbrock, S. Fischer & E. D. Gilles

Metabolic networks:  Biology meets Engineering Sciences

12

Dirk Müller, Luciano Aguilera-Vázquez, Matthias Reuss & Klaus Mauch

Integration of metabolic and signaling networks

 

SIGNAL TRANSDUCTION

 

13

Reinhart Heinrich

Mathematical modelling of the Wnt-pathway

14

Bodil Nordlander, Edda Klipp, Bente Kofahl & Stefan Hohmann

Modelling signallng pathways – A yeast approach

 

LIFE AND DEATH

 

15

Béla Novák, Katherine C. Chen and John J. Tyson

Systems Biology of the yeast cell cycle engine

16

M. Bentele & Roland Eils

Systems Biology of Apoptosis

17

Hiroaki Kitano

Scientific and technical challenges for Systems Biology

 

EPILOGUE

 

18

Lilia Alberghina, Stefan Hohmann and Hans V. Westerhoff

Systems Biology: recent developments and new trends